2022 NCAA Tournament bracket: Opening lines, odds, spreads for March Madness Sweet 16 games

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Second round play of the 2022 NCAA Tournament came to a close on Sunday night and after a frenetic four-day affair that featured more than 50 games, we’re almost down to only 16 teams still standing. With matchups set and the bracket starting to take shape, odds courtesy of Caesars Sportsbook are already out that demand your attention as you gear up for another week of games.

For as unpredictable as the tournament is — and has been — betting odds can be predictive in helping you handicap if you’re gambling or just trying to get an idea of how the public views each matchup. Odds below suggest we’re in for an equally fun second weekend of action as the list of contenders slowly shrinks.

No team is favored by more than — who else? — the No. 1 overall seed in Gonzaga among opening lines. The Zags are -8.5 vs. No. 4 seed Arkansas. Fellow No. 1 seed Kansas is a pretty big favorite as well over its No. 4 seed foe, Providence, with a 7.5-point spread. No. 2 seed Villanova and No. 4 seed UCLA also have a slight edge in the eyes of oddsmakers, but the spread for those favorites are much closer, suggesting we could be in for some close contests to open up the second weekend of March Madness next week.

The current odds via Caesars Sportsbook are below.

Sweet 16 odds


Thursday at San Francisco

  • (1) Gonzaga -8.5 vs. (4) Arkansas
  • (2) Duke (+1) vs. (3) Texas Tech


Thursday at San Antonio

  • (1) Arizona -2 Houston
  • (2) Villanova -4.5 vs. (11) Michigan


Friday at Chicago

  • (1) Kansas -7.5 vs. (4) Providence
  • (10) Miami vs. (11) Iowa State PK


Friday at Philadelphia

  • (4) UCLA -2 vs. (8) North Carolina
  • (3) Purdue -12.5 vs. (15) Saint Peter’s

Who wins every college basketball game, and which teams will sink your bankroll? Visit SportsLine now to see how to pick the spread, over-under, and money line in each tournament game, all from the model that’s up almost $1,500 on top-rated college basketball picks and simulates every possession 10,000 times.

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