49ers vs. Commanders odds, picks, how to watch, live stream, start time: Model’s 2022 Week 16 NFL predictions

Brock Purdy and the San Francisco 49ers will host Taylor Heinicke and the Washington Commanders in an NFC showdown on Saturday on CBS and Paramount+. San Francisco is enjoying success, having won six straight, and enters Week 16 having already clinched the NFC West and secured a playoff berth. Meanwhile, the visiting Commanders will aim to win their first game since November 27, tallying a tie and a loss against the New York Giants in consecutive games. You can stream the game in select markets on Paramount+, and you can get your first year for 50% off when you use promo code ALLYEAR from now until 12/31.

Kickoff from Levi’s Stadium in Santa Clara, California is set for 4:05 p.m. ET. The 49ers are 6.5-point favorites in the latest 49ers vs. Commanders odds from Caesars Sportsbook, and the over/under for total points is 37.5. Saturday’s matchup can be seen live on CBS and streamed live in select markets on Paramount+ with their must-have Premium plan.

Paramount+ now has levels of membership so you can watch your local NFL on CBS matchups and much more. The Essential Plan costs $4.99 per month to access Paramount’s catalog of movies and TV shows with limited advertisements, plus your live local NFL games, international soccer and more.  The Premium Plan is $9.99 per month and you can watch your local CBS live stream, including plenty of sports like SEC on CBS, NFL on CBS, and the PGA Tour, with no ads, on demand and the ability to download episodes for offline viewing. You can now get 50% off one year of the Paramount+ Essential or Premium plan with code ALLYEAR. Offer valid until 12/31, so sign up now here.

How to watch Commanders vs. 49ers

  • 49ers vs. Commanders date: Saturday, Dec. 24
  • 49ers vs. Commanders time: 4:05 p.m. ET
  • 49ers vs. Commanders TV channel: CBS 
  • 49ers vs. Commanders streaming: Paramount+ (use promo code ALLYEAR for half-off your first year)

Week 16 NFL picks for Commanders vs. 49ers

Before tuning into Saturday’s 49ers vs. Commanders game, you need to see the NFL picks from SportsLine’s advanced computer model. The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 16 of the 2022 NFL season on an incredible 157-113 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

For 49ers vs. Commanders, the model is picking San Francisco to cover the spread. A key to San Francisco’s success over their seven game winning streak has been the Nick Bosa-led defense, which will get a boost in Week 16 with the long-awaited return of Arik Armstead to the gridiron. Washington may want to rely on its run game on Saturday, but that will be difficult against a 49ers defense that is only allowing 3.4 yards per carry.

Purdy has been relentless with six touchdowns in three games and just one interception. Expect an uphill battle for Washington on Saturday. You may be able to stream the game here.

How to watch, live stream the NFL on CBS

Now that you know what to pick, get ready to watch your live local NFL on CBS games on Paramount+ on any device you want. Visit Paramount+ now to stream your live local CBS sporting events, including the NFL, SEC on CBS, and so much more. Get your first year for 50% off with the promo code ALLYEAR here.

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